There was no physical trace of Amanda Knox or Rafaelle Sollecito in the room where British student Meredith Kercher was found murdered nearly four years ago, Sollecito’s defense attorney said Tuesday as she began her closing arguments.

“The room speaks only of Rudy” Guede, the other man convicted separately of killing Kercher, Giulia Buongiorno told a jury in Perugia, Italy, where Knox and Sollecito are fighting their conviction for the murder.

Knox and Sollecito were convicted in 2009. Knox was sentenced to 26 years in prison, while Sollecito got 25.

Knox and Sollecito’s defense teams have suggested Guede, who is already serving a 16-year sentence, could have been the sole killer.

Evidence that Guede was in the room shows that “no one could enter that room and not leave any trace,” said Buongiorno, who represents Sollecito.

She urged the jury to think about her client as they made their decision.

“The lives of this kid and his parents have been destroyed. You must today evaluate if – if – if these kids committed the crime,” Buongiorno told jurors.

Buongiorno, one the highest-profile lawyers in Italy, attacked media coverage of the trial as sensational, saying it could have affected what witnesses told the court.

And she compared Knox to the voluptuous cartoon character Jessica Rabbit, who protests, “I’m not bad, I’m just drawn that way,” in the movie “Who Framed Roger Rabbit?”

Buongiorno rejected the notion that Knox and Sollecito were into violent sex, saying they rubbed noses in “Eskimo kisses.”

The lawyer also attacked the circumstances under which Knox was interrogated by police the night of the murder, saying she was interrogated by “hostile” officers, which made it impossible to trust what she said that night.

“If one is not calm, anything can happen,” Buongiorno argued.

And she hammered home attacks on DNA evidence that have been a key part of the appeal.

She said police could have contaminated the crime scene or the evidence, playing video from the police investigation itself to make her point.

Knox and Sollecito are appealing the convictions together, having been convicted in a joint trial.

Both defendants were in court Tuesday, with Knox in a long-sleeved pink sweater and Sollecito in a long-sleeved prune-colored shirt. Their parents were in court as well.

On Monday, the lawyer for Kercher’s family showed photos of the British murder victim’s bloodied body, pointing out multiple stab wounds. He urged the Italian jury not to overturn Knox and Sollecito’s convictions.

“I show you these pictures to show you the pain of Meredith,” Francesco Maresca said.

“She didn’t have defensive wounds. It means that she was tied up, that she had more than one aggressor,” the lawyer said.

“Given the type, number and locations of the wounds, there had to be multiple attackers,” he insisted.

He attacked as “useless” a review of DNA evidence that may cast doubt on the original convictions.

Knox avoided looking at the photographs of Kercher’s body as they were shown.

Lawyers for the civil suits related to the case presented their closing arguments Monday.

At the hearing, another lawyer called Knox two-faced and “diabolical.”

“Within her lives a double soul: one which is angelic, good, compassionate … tender and ingenuous,” Carlo Pacelli said.

But she had another side, he said: “A Lucifer-like, demonic, satanic, diabolical one which sometimes leads her to borderline and dissolute behavior,” saying that was the Knox who had killed her roommate.

Pacelli sought to portray Knox as sexually promiscuous and a difficult roommate as he fights for damages for his client, Patrick Lumumba.

Knox accused Lumumba of the murder in 2007. He was arrested but released after his alibi checked out. He later sued Knox for libel, winning 40,000 euros ($54,000) in damages.

Defense attorneys for Knox are expected to present their final arguments Thursday.

A verdict could come as soon as October 3.