Iowa State hung close throughout the first half but ultimately fell to a 613-yard barrage from top-ranked Oklahoma in a 53-7 home loss Saturday.

The Cyclone offensive and defensive lines both suffered key injuries and were physically manhandled by their Oklahoma counterparts. ISU freshman quarterback Austin Flynn threw two interceptions and was just 6-of-17 passing for 88 yards. He added 49 yards as the Cyclones’ leading rusher on 19 carries, but he was sacked six times.

Sooner quarterback Jason White had the best game of his career, tying an Oklahoma record with five touchdown and setting a personal career best with 26 completions on 34 attempts for 384 yards without an interception. A sixth touchdown pass was called back after a holding penalty.

“I don’t know if we laid a hand on him all night,” said ISU head coach Dan McCarney. “I thought his accuracy was outstanding.”

The Sooners led just 9-0 with five minutes left in the first half, but senior receiver Jack Whitver fumbled after a 14-yard reception and Oklahoma returned the ball four yards to the ISU 39-yard line.

On the next play, the Sooners’ Mark Bradley made a diving catch in the end zone behind two ISU defensive backs to put Oklahoma up 16-0. The Sooners would add Mark Clayton’s 24-yard touchdown catch with 28 seconds left to lead 22-0 at halftime and initiate the rout.

Iowa State’s only points came early in the fourth quarter when blitzing safety JaMaine Billups intercepted an attempted screen pass by Sooner reserve quarterback Paul Thompson and raced 77 yards to the end zone, cutting the lead to 39-7.

But Bradley returned the ensuing kickoff 100 yards for a touchdown without being touched by a Cyclone defender.

It was Oklahoma’s third straight game topping 50 points.

“They’re a very, very fast, athletic football team,” ISU head coach Dan McCarney said. “We’ll get this one behind us just as fast as we can.”

Oklahoma’s 613 net yards — 199 rushing, 414 passing — were the third-most ever allowed by an ISU team in McCarney’s nine seasons, the most since Baylor rolled to 624 yards in a 49-21 victory in 1996.

After returning three punts for touchdowns in the Sooners’ last game against UCLA, Oklahoma returner Antonio Perkins was stymied by the Cyclones. Playing for the first time after suffering a leg injury against Ohio Sept. 6, ISU punter Tony Yelk averaged 41.5 yards on eight punts, and Perkins was held to minus-one yards on three returns.

Iowa State missed several chances to score early in the game. With the Sooners leading 3-0 late in the first quarter, Perkins fumbled his first punt return at the Oklahoma 17, but Eric Bassey fell on it.

Early in the second quarter, with the score still 3-0, Iowa State faked a punt when Yelk completed a 10-yard pass to linebacker Nik Moser for a first down. But the play was called back because the Cyclones only had six men on the line of scrimmage.

Down 9-0, the Cyclones had another chance for a turnover when Moser stripped the ball from receiver Will Peoples, but the Sooners’ Brandon Jones fell on it at the Oklahoma 43.

“Our kids really fought,” McCarney said. “We were outmanned.”

The Cyclones travel to Texas Tech next weekend, owning a sub-.500 record (2-3, 0-1 Big 12) this late in the season for the first time since 1999. The No. 1 Sooners (5-0, 1-0 Big 12) will face No. 13 Texas in Dallas next Saturday.

Iowa State fell to 0-10 all-time against No. 1 ranked opponents and suffered its ninth straight loss to Oklahoma.