Oklahoma quarterback Kyler Murray had over 400 yards of offense and the No. 5-ranked Sooners held on to beat Iowa State in Ames on Saturday, 37-27.

Redshirt sophomore Zeb Noland got the start for the Cyclones ahead of an injured Kyle Kempt. 

Oklahoma scored first, capping off a long drive with a 21-yard field goal from Austin Seibert to take a 3-0 first-quarter lead.

Following a third-down conversion, Oklahoma broke out a 75-yard touchdown pass from Kyler Murray to Marquise Brown to push the lead to 10-0. 

After a field goal, a forced fumble by redshirt sophomore safety Greg Eisworth and a recovery from redshirt freshman safety Richard Bowens, the Cyclones tied the game on a 51-yard touchdown pass from Noland to redshirt junior Hakeem Butler, with Butler breaking four tackles on his way to the end zone. 

Oklahoma came back with a 75-yard drive and a touchdown pass from Murray to CeeDee Lamb to go back up 17-10 with 7:47 left in the first half of action. 

Iowa State was unable to answer, and after a punt, the Sooners drove right down the field before the half, scoring on a Kyler Murray pass to Myles Tease to take a 24-10 lead into the half. 

At the half, Oklahoma had 354 yards of total offense and Murray had 317 yards by himself. Iowa State had 193 yards of offense, five more than the Cyclones had all game against the Hawkeyes.

Brown set the Oklahoma school record with 189 yards receiving on seven receptions. 

After forcing an Oklahoma three-and-out to start the second half, the Cyclones crept back within seven on another Hakeem Butler touchdown, this one going for 57 yards.

The Sooners hit back with an efficient touchdown drive capped by a 22-yard run by Trey Sermon to push the lead to two touchdowns once again.

The Cyclones roared back after a Sooner field goal with another score set up by a long reception from Butler. Junior running back David Montgomery punched it in from one-yard out, and the Cyclones were back within a touchdown. 

The Cyclones opened the scoring in the fourth with a 28-yard field goal from Assalley, once again back within seven of the Sooners. The Sooners tacked on a field goal, and Noland threw a pick with 1:11 left to seal the game.